Cardiac myxoma with cartilaginous differentiation-An uncommon variant presented as mitral stenosis

The estimated incidence of primary cardiac tumors is extremely rare. Among it, cardiac myxoma represents the most common benign cardiac tumor constituting about 80% of cases. We are presenting a 30–year-old female with large left atrial myxoma. She was presented with severe dyspnea, palpitations, and systolic murmurs. On 2D echocardiography, left atrial mass obstructing mitral flow was noted. On cardiac magnetic resonance imaging, a single, large, mobile pedunculated mass lesion in left atrium attached to inferior interatrial septum with heterogeneous enhancement was noted, which was likely represented to be myxoma. The mass was surgically excised and valve repairing was done. We received large, solid, lobulated, gray white, soft-to-firm mass measuring 4.5 × 4.1 × 2.5 cm, and on microscopy showed cardiac myxoma with cartilaginous differentiation. We are presenting this case for its clinical, imaging, and uncommon histological features.

Antimicrobial resistance of staphylococci and streptococci isolated from dogs

@#A study was conducted for the examination of bacterial species isolated in dogs from Animal Clinics of Nanjing Agricultural University, China. Forty nasal swabs were taken from dogs having respiratory signs. Staphylococcus pseudintermedius was the most frequently isolated pathogen (37.50 %) followed by Staphylococcus aureus (18.75%), Streptococcus pluranimalium (10.93%), Streptococcus canis (9.37%), Staphylococcus schleiferi (9.37%), Staphylococcus intermedius (6.25%), Staphylococcus cohnii (4.71%) and Staphylococcus hominis (3.12%). S. pseudintermedius and S. pluranimalium were subjected to commonly used antibiotics for determination of resistant drugs. Antimicrobial resistance in S. pseudintermedius was common in gentamicin (70.83%) and tetracycline (50%) while in S. pluranimalium was common in enrofloxacin (71.42%) and gentamicin (57.14%).

Congenital Thrombotic Thrombocytopenic Purpura: An Unusual Case of Microangiopathic Haemolytic Anaemia in a Newborn.

We present an extremely rare case of hyperbilirubinemia with rapid progression leading to bilirubin encephalopathy in term neonate. Despite early recognition and intervention, death occurred as a total serum bilirubin reached 25 mg/dl. It was a case of Coomb’s negative microangiopathic haemolytic anaemia in a newborn period which is autosomal recessive inheritance i.e. Upshaw-Schulman Syndrome. (Congenital thrombotic thrombocytopenic purpura) characterised by numerous schistocytes on peripheral blood smear, thrombocytopenia , increased reticulocyte count, increased bilirubin and LDH level. This rare disease is often misdiagnosed especially in newborn baby. So we present this case not only for its variety but also for to create more awareness among pathologist and paediatrician as treatment protocol entirely differ.

Obstetric Profile of Primi Teenage and Non-teenage mothers: A comparative study from Maharashtra, India.

Introduction: Early marriages and teenage pregnancies are important contributing factors for high maternal as well as neo-natal morbidity and mortality. Objectives: To assess the magnitude of obstetric profile of teenage and non-teenage primi mothers and to determine the association among them. Methodology: A cross-sectional study was conducted at OB/Gynac clinic Krishna hospital Karad over a period of first quarter of year 2012. 93 eligible teenage primi mothers and equal number of non-teenage primi mothers admitted to Krishna hospital for delivery were enrolled, interviewed and observed for socio-demographic, obstetric outcome and it’s complications by investigator according to pre- designed structured proforma. Frequency percentage distribution and association was determined by applying tests of significance. Observations: Magnitude of teenage primi pregnancy was 6% during study period and most of them 92.50%, 76.30% and 46.20% were Hindus, housewives and belonged to lower class by religion, occupation and economically with mean age at marriage and delivery was 17.8 yrs and 18.8 yrs respectively. Max. 81.7% teenage primi mothers were anaemic and the percentage of obstetric complications like PIH, Oligohydramnios, PROM, Foetal distress among teenage primi mothers was 24%,8.6%, 1%, and 6.4% which was higher than nonteenage mothers. IUGR, cord prolapse, breech presentation and abruption placenta also reported among teenage primi mothers, however absent among non-teenage mothers. Max 55.9% teenage mothers were delivered before expected date of delivery and proportion of low birth weight baby was also high (39.8%) in teenage mothers than non-teenage mothers. Chance of delivery of male baby also increases as age at marriage increases. Conclusion: Adolescent pregnancy is an issue that calls for more education & support to encourage girls to delay motherhood until they are ready.

U.V.Spectrophotometric Method development for Capecitabine in Eudragit and chitosan based Mecrospheres and its Validation.

A simple, rapid, accurate, precise, and economic Spectrophotometric method for Capecitabine in bulk and formulated microspheres dosage form has been developed. Capecitabine shows absorbance maximum at different wavelength in different solvents, so absorbance was measured and the same wavelengths used for the estimation of Capecitabine in respective solvents. Capecitabine obey the beer lamberts’ law. Method is validated according to ICH guideline and carried out for analysis of Capecitabine in pure and formulated microsphere dosage form.

Consumer grievance reporting in G.M.C. Hospital, Miraj.

A cross-sectional study conducted among 400 'consumers' at G.M.C. Hospital, Miraj revealed 91% consumers had one/more grievance/s. Higher grievances reported in illiterates, lower social class, indoor patients, surgical patients. Lower grievances reported in age < 15 yrs and 31-45 yrs, rural dwellers. Sex and new / old status of patients not affected grievance- reporting. 10 grievances out of 38 were found to be of serious nature. Some grievances (e.g. post-operative complications, discharge without clinical relief, absence of counselling, cursory clinical examination etc.) might have potential as possible medical negligence.